Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 18/20 | 0.60 |
| ▸ | MMP13 | P45452 | 18/20 | 0.60 |
| ▸ | MMP1 | P03956 | 16/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 15/20 | 0.60 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.43 |
| ▸ | MMP12 | P39900 | 3/20 | 0.43 |
| ▸ | MMP14 | P50281 | 3/20 | 0.43 |
| ▸ | MMP16 | P51512 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313714 | 0.92 | MMP1 (0.51) | MMP9MMP13MMP1ADAM17HTR6 | |
| SCHEMBL7316388 | 0.83 | MMP9 (0.67) | MMP9MMP13MMP1ADAM17HTR6 | |
| SCHEMBL7817382 | 0.82 | MMP9 (0.71) | MMP9MMP13MMP1ADAM17HTR6 | |
| SCHEMBL7315174 | 0.79 | MMP9 (0.51) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7315611 | 0.78 | MMP9 (0.57) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7447578 | 0.75 | MMP9 (0.59) | MMP9MMP13MMP1ADAM17HTR6 | |
| SCHEMBL6852400 | 0.75 | MMP9 (1.00) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7316213 | 0.74 | MMP1 (0.57) | MMP9MMP13MMP1ADAM17HTR6 | |
| SCHEMBL7323224 | 0.74 | MMP1 (0.57) | MMP9MMP13MMP1ADAM17HTR6 | |
| SCHEMBL7325380 | 0.74 | MMP9 (0.68) | MMP9MMP13MMP1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |