Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 7/20 | 0.57 |
| ▸ | MMP9 | P14780 | 7/20 | 0.57 |
| ▸ | MMP13 | P45452 | 7/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.57 |
| ▸ | HTR6 | P50406 | 5/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323224 | 0.92 | MMP1 (0.57) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7316388 | 0.91 | MMP9 (0.67) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7315611 | 0.83 | MMP9 (0.57) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7313714 | 0.82 | MMP1 (0.51) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7325380 | 0.80 | MMP9 (0.68) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL7318156 | 0.80 | MMP1 (0.59) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7320044 | 0.80 | MMP1 (0.60) | MMP1MMP9MMP13ADAM17CYP3A4 | |
| SCHEMBL7448969 | 0.80 | MMP1 (0.67) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7316221 | 0.78 | MMP1 (0.81) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7816811 | 0.78 | MMP1 (0.50) | MMP1MMP9MMP13ADAM17HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |