Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | HRH2 | P25021 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | HTR1B | P28222 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.62 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.54 |
| ▸ | SCN4A | P35499 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314306 | 0.88 | SCN3A (0.61) | DRD2DRD3HRH2ADRA2ADRD4 | |
| Hydrochloric Acid SCHEMBL7316817 | 0.87 | ADRA2A (0.66) | DRD2DRD3HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL35376 | 0.77 | DRD3 (1.00) | DRD2DRD3HRH2ADRA2ADRD4 | |
| Dexpramipexole SCHEMBL74780 | 0.77 | DRD3 (1.00) | DRD2DRD3HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL195775 | 0.77 | DRD3 (1.00) | DRD2DRD3HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL4797279 | 0.77 | DRD3 (0.92) | DRD2DRD3HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL42113 | 0.76 | ADRA2A (1.00) | DRD2DRD3HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL3947668 | 0.76 | DRD3 (0.97) | DRD2DRD3HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL20524815 | 0.76 | DRD3 (0.97) | DRD2DRD3HRH2ADRA2ADRD4 | |
| Dexpramipexole SCHEMBL910147 | 0.76 | ADRA2A (1.00) | DRD2DRD3HRH2ADRA2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4886812-A | REGULATING DOPAMINE CONCENTRATION; PARKINSON DISEASE, HYPOTENSIVE AGENT, SCHIZOPHRENIA | DR. KARL THOMAE GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| US-4843086-A | HYPOTENSIVE AGENTS, SCHIZOPHRENIA, PARKINSON'S DISEASE | BOEHRINGER INGELHEIM KG (DE) | 1989-06-27 | — | — | US | disclosed |
| US-4731374-A | PARKINSON*S DISEASE | DR. KARL THOMAE GMBH (DE) | 1988-03-15 | — | — | US | disclosed |
| EP-0186087-A1 | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs | Dr. Karl Thomae GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |