SCHEMBL7316731

SCHEMBL7316731

CCCCCCCCN(C)C(=O)CCc1cc(C)c(N(C)S(=O)(=O)c2ccc(OC)cc2)c(C(=O)NO)c1

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 20/20 0.60
MMP9 P14780 19/20 0.60
ADAM17 P78536 17/20 0.60
MMP1 P03956 14/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7323519 0.92 MMP9 (0.49) MMP13MMP9ADAM17MMP1
SCHEMBL7324723 0.91 MMP13 (0.47) MMP13MMP9ADAM17MMP1
SCHEMBL7322134 0.90 MMP13 (0.68) MMP13MMP9ADAM17MMP1
SCHEMBL7825679 0.85 MMP13 (0.44) MMP13MMP9ADAM17MMP1
SCHEMBL7453357 0.84 MMP13 (0.57) MMP13MMP9ADAM17MMP1
SCHEMBL7453436 0.82 MMP13 (0.58) MMP13MMP9ADAM17MMP1
SCHEMBL7312722 0.82 MMP13 (0.58) MMP13MMP9ADAM17MMP1
SCHEMBL7323855 0.79 MMP13 (0.53) MMP13MMP9ADAM17MMP1
SCHEMBL7318221 0.79 MMP13 (0.83) MMP13MMP9ADAM17MMP1
SCHEMBL7576696 0.78 BCHE (0.43) MMP13MMP9ADAM17MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP claimed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP claimed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO claimed
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed