Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.47 |
| ▸ | MMP9 | P14780 | 7/20 | 0.47 |
| ▸ | MMP1 | P03956 | 6/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323519 | 0.92 | MMP9 (0.49) | MMP13MMP9MMP1ADAM17BCHE | |
| SCHEMBL7316731 | 0.91 | MMP13 (0.60) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7323855 | 0.89 | MMP13 (0.53) | MMP13MMP9MMP1ADAM17CNR2 | |
| SCHEMBL7506542 | 0.81 | MMP9 (0.45) | MMP13MMP9MMP1ADAM17CNR2 | |
| SCHEMBL7310943 | 0.81 | MMP9 (0.45) | MMP13MMP9MMP1ADAM17CNR2 | |
| SCHEMBL7576696 | 0.80 | BCHE (0.43) | MMP13MMP9MMP1ADAM17BCHE | |
| SCHEMBL7825679 | 0.79 | MMP13 (0.44) | MMP13MMP9MMP1ADAM17BCHE | |
| SCHEMBL7322134 | 0.79 | MMP13 (0.68) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7322108 | 0.77 | MMP13 (0.55) | MMP13MMP9MMP1ADAM17TAS2R14 | |
| SCHEMBL7324075 | 0.77 | MMP13 (0.56) | MMP13MMP9MMP1ADAM17CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| CN-1240429-A | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors | AMERICAN CYANAMID CO (US) | 2000-01-05 | — | — | CN | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |