Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | LDHB | P07195 | 1/20 | 0.43 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330422 | 0.83 | KDM4E (0.52) | ALDH1A1KDM4EPDE4AMAPTSMN1; SMN2 | |
| SCHEMBL7330415 | 0.83 | KDM4E (0.52) | ALDH1A1KDM4EPDE4AMAPTSMN1; SMN2 | |
| SCHEMBL14300697 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KDM4ELMNAPDE4AMAPT | |
| SCHEMBL14300696 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KDM4ELMNAPDE4AMAPT | |
| SCHEMBL6385751 | 0.83 | PDE4A (0.69) | ALDH1A1KDM4ELMNAPDE4ALDHA | |
| SCHEMBL1409530 | 0.79 | PSEN1 (0.42) | ALDH1A1KDM4EPDE4AMAPTTP53 | |
| SCHEMBL30861661 | 0.79 | KDM4E (0.52) | ALDH1A1KDM4ELMNALDHALDHB | |
| SCHEMBL1806721 | 0.79 | KDM4E (0.52) | ALDH1A1KDM4ELMNALDHALDHB | |
| SCHEMBL1116276 | 0.79 | HTRA2 (0.56) | ALDH1A1KDM4ELMNAPDE4ALDHA | |
| SCHEMBL1409527 | 0.78 | FDPS (0.44) | ALDH1A1KDM4ELMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882354-A | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0321431-A1 | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-06-21 | — | — | EP | disclosed |