Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.67 |
| ▸ | DRD1 | P21728 | 2/20 | 0.67 |
| ▸ | DRD3 | P35462 | 2/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | HTR2C | P28335 | 1/20 | 0.67 |
| ▸ | HRH1 | P35367 | 1/20 | 0.67 |
| ▸ | HTR2B | P41595 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3919536 | 0.91 | OPRM1 (0.78) | OPRM1CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL8186671 | 0.91 | OPRM1 (0.78) | OPRM1CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL8175607 | 0.91 | OPRM1 (0.78) | OPRM1CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL7977689 | 0.91 | OPRM1 (0.78) | OPRM1CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL16448455 | 0.84 | OPRM1 (0.70) | OPRM1CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL8176312 | 0.82 | OPRM1 (0.67) | OPRM1CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL2054235 | 0.81 | CYP2D6 (0.67) | OPRM1CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL1502253 | 0.81 | CYP2D6 (0.65) | OPRM1CHRM2ADRA2ACHRM1DRD1 | |
| Cyclizine SCHEMBL4690 | 0.80 | CYP2D6 (1.00) | OPRM1CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL467087 | 0.80 | OPRM1 (0.64) | OPRM1CHRM2ADRA2ACHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159566-A1 | Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient | KANEBO, LTD. (JP) | 1985-10-30 | — | — | EP | claimed |
| WO-2012077133-A1 | PROCESSES FOR PREPARATION OF MONTELUKAST SODIUM AND PURIFICATION OF DIOL INTERMEDIATE | IND-SWIFT LABORATORIES LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |
| US-4663325-A | 1-(2,3,4-tri-methoxybenzyl)-4[bis(4-fluorophenyl)methyl] piperazines are useful for treating cerebrovascular disease | KANEBO LTD. (JP) | 1987-05-05 | — | — | US | disclosed |
| US-4663325-A | 1-(2,3,4-tri-methoxybenzyl)-4[bis(4-fluorophenyl)methyl] piperazines are useful for treating cerebrovascular disease | KANEBO LTD. (JP) | 1987-05-05 | — | — | US | disclosed |
| EP-0159566-A1 | Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient | KANEBO, LTD. (JP) | 1985-10-30 | — | — | EP | disclosed |
| EP-0159566-A1 | Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient | KANEBO, LTD. (JP) | 1985-10-30 | — | — | EP | disclosed |