Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 7/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27550706 | 0.89 | TDP1 (0.54) | TDP1L3MBTL1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL1161744 | 0.87 | TDP1 (0.49) | TDP1L3MBTL1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL395027 | 0.87 | TDP1 (0.62) | TDP1L3MBTL1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL2598195 | 0.87 | TDP1 (0.49) | TDP1L3MBTL1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL30527914 | 0.87 | TDP1 (0.62) | TDP1L3MBTL1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL28590951 | 0.87 | TDP1 (0.53) | TDP1L3MBTL1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL7436564 | 0.85 | TDP1 (0.47) | TDP1L3MBTL1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL10908841 | 0.84 | ALDH1A1 (0.52) | TDP1L3MBTL1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL28307884 | 0.83 | TDP1 (0.45) | TDP1L3MBTL1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL7988682 | 0.82 | ALDH1A1 (0.50) | TDP1L3MBTL1ALDH1A1TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329675-B2 | Substituted azabicyclic compounds | AVENTIS PHARMA LIMITED (GB) | 2008-02-12 | — | — | US | disclosed |
| US-6245716-B1 | LOW DOSAGE; NONPHYTOTOXIC | NIPPON SODA CO., LTD. (JP) | 2001-06-12 | — | — | US | disclosed |
| US-RE31617-E | ANTICOAGULANTS; HYPOTENSIVE AND BRONCHODILATOR AGENTS | BRISTOL-MYERS COMPANY (US) | 1984-06-26 | — | — | US | disclosed |
| US-3932407-A | BRONCHODILATORS, HYPOTENSIVE AGENTS, ANTICOAGULANTS | BRISTOL-MYERS COMPANY (US) | 1976-01-13 | — | — | US | disclosed |