Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.65 |
| ▸ | HTR3A | P46098 | 3/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8133261 | 0.82 | HTR1A (0.54) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL1307818 | 0.82 | DRD2 (0.58) | HTR1ADRD2DRD3PRMT5WDR77 | |
| SCHEMBL14560018 | 0.81 | HTR1A (0.53) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL14570847 | 0.81 | HTR1A (0.59) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL4274174 | 0.81 | HTR3E (0.60) | HTR3AHTR6HTR3EHTR3BHTR3D | |
| SCHEMBL7322168 | 0.80 | HTR1A (0.62) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL8139551 | 0.79 | PRMT5 (0.52) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL14570779 | 0.79 | HTR1A (0.57) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL4673484 | 0.79 | HTR1A (1.00) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| Bicarbonate SCHEMBL11620055 | 0.79 | DRD2 (0.84) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843948-A | Piperazinophenyl- and piperazinophenyloxycarboxylic acid derivatives, and processes and intermediates for their preparation and pharmaceutical compositions comprising them | SOLVAY PHARMACEUTICALS GMBH (DE) | 1998-12-01 | — | — | US | disclosed |