Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.70 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.70 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.70 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.70 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | BRD4 | O60885 | 2/20 | 0.70 |
| ▸ | CNR1 | P21554 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.69 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | PTAFR | P25105 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29369120 | 0.89 | GABRA1 (0.79) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL7327360 | 0.89 | GABRA1 (0.79) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11716522 | 0.87 | OPRK1 (0.53) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL23881490 | 0.86 | GABRA1 (0.70) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL30089318 | 0.86 | GABRA1 (0.70) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL23881525 | 0.86 | PTAFR (0.80) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11537673 | 0.85 | OPRK1 (0.51) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL23881599 | 0.84 | PTAFR (0.63) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL23881598 | 0.84 | PTAFR (0.58) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11378371 | 0.84 | OPRK1 (0.56) | GABRA1GABRA5GABRA2GABRB2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | claimed |
| US-4000153-A | TRANQUILIZERS, SEDATIVES | THE UPJOHN COMPANY (US) | 1976-12-28 | — | — | US | disclosed |
| US-4000151-A | TRANQUILIZERS, SEDATIVES | THE UPJOHN COMPANY (US) | 1976-12-28 | — | — | US | disclosed |
| US-4000289-A | 6-PHENYL-4H-S-TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1976-12-28 | — | — | US | disclosed |
| US-3993660-A | 2-[3-(Phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenones | THE UPJOHN COMPANY (US) | 1976-11-23 | — | — | US | disclosed |
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3984545-A | 3,4-DIHYDROXY-PHENYL-1-ANALINE WITH BENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1976-10-05 | — | — | US | disclosed |