Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CCND3 | P30281 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317623 | 0.84 | TP53 (0.38) | GSK3BCDK2ALDH1A1 | |
| SCHEMBL10943341 | 0.82 | NTRK1 (0.40) | GSK3BCDK2CDK4CCND1CDK1 | |
| Flosequinan SCHEMBL5441172 | 0.82 | ATM (0.47) | GSK3BCDK2CDK4CCND1CCNE2 | |
| Flosequinan SCHEMBL5442796 | 0.82 | ATM (0.47) | GSK3BCDK2CDK4CCND1CCNE2 | |
| Flosequinan SCHEMBL122877 | 0.82 | ATM (0.47) | GSK3BCDK2CDK4CCND1CCNE2 | |
| SCHEMBL11406579 | 0.81 | HTR1D (0.39) | ALDH1A1 | |
| Flosequinan SCHEMBL6535622 | 0.81 | ATM (0.46) | GSK3BCDK2CDK4CCND1CCNE2 | |
| SCHEMBL11401644 | 0.81 | KDM4E (0.31) | CNR1CNR2ALDH1A1 | |
| SCHEMBL11401796 | 0.80 | ALDH1A1 (0.52) | GSK3BALDH1A1 | |
| SCHEMBL11398354 | 0.80 | SCN9A (0.33) | GSK3BCDK5TYRO3SCN9AMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4552884-A | Method of treating heart disease | THE BOOTS COMPANY PLC (GB) | 1985-11-12 | — | — | US | disclosed |
| EP-0149519-A2 | Use of quinolones for the manufacture of a composition for the treatment of heart failure. | The Boots Company PLC (GB) | 1985-07-24 | — | — | EP | disclosed |
| US-4302460-A | 4-Quinolinones having antihypertensive activity | THE BOOTS COMPANY LIMITED (GB) | 1981-11-24 | — | — | US | disclosed |