Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.61 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 12/20 | 0.51 |
| ▸ | DRD2 | P14416 | 10/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1443153 | 0.87 | DRD2 (0.68) | HTR2CHTR1ACYP2D6TSHRPMP22 | |
| SCHEMBL1427955 | 0.86 | DRD2 (0.50) | HTR2CHTR1ACYP2D6TSHRPMP22 | |
| SCHEMBL9050419 | 0.85 | ADRA2A (0.52) | HTR2CHTR1ACYP2D6TSHRPMP22 | |
| SCHEMBL7701569 | 0.84 | HTR2C (0.61) | HTR2CHTR1ACYP2D6TSHRPMP22 | |
| SCHEMBL9050924 | 0.82 | DRD2 (0.44) | HTR2CHTR1ACYP2D6TSHRPMP22 | |
| SCHEMBL9050755 | 0.82 | DRD2 (0.45) | HTR2CHTR1ACYP2D6TSHRPMP22 | |
| SCHEMBL9491933 | 0.82 | HTR2C (0.61) | HTR2CHTR1ACYP2D6TSHRPMP22 | |
| SCHEMBL1119172 | 0.80 | DRD2 (0.75) | HTR2CHTR1ACYP2D6TSHRPMP22 | |
| SCHEMBL5328181 | 0.80 | DRD2 (0.75) | HTR2CHTR1ACYP2D6TSHRPMP22 | |
| SCHEMBL4616132 | 0.79 | DRD2 (0.53) | HTR2CHTR1ACYP2D6TSHRPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196132-A2 | 1,2-Benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-10-01 | — | — | EP | disclosed |