Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 0.45 |
| ▸ | MMP12 | P39900 | 12/20 | 0.45 |
| ▸ | MMP13 | P45452 | 11/20 | 0.45 |
| ▸ | MMP14 | P50281 | 11/20 | 0.45 |
| ▸ | MMP8 | P22894 | 10/20 | 0.45 |
| ▸ | MMP16 | P51512 | 10/20 | 0.45 |
| ▸ | MMP9 | P14780 | 11/20 | 0.43 |
| ▸ | MMP3 | P08254 | 8/20 | 0.43 |
| ▸ | MMP1 | P03956 | 6/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313017 | 0.97 | MMP2 (0.44) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL7316017 | 0.92 | MMP2 (0.43) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL7325271 | 0.91 | MMP2 (0.44) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL7314682 | 0.90 | MMP2 (0.47) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL7322110 | 0.89 | MMP2 (0.46) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL7317813 | 0.89 | MMP2 (0.49) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL7321209 | 0.86 | MMP2 (0.41) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL7318741 | 0.85 | MMP13 (0.43) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL7311793 | 0.85 | MMP1 (0.48) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL7315558 | 0.85 | MMP2 (0.46) | MMP2MMP12MMP13MMP14MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |