Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.45 |
| ▸ | MMP13 | P45452 | 8/20 | 0.45 |
| ▸ | MMP9 | P14780 | 8/20 | 0.45 |
| ▸ | MMP1 | P03956 | 8/20 | 0.45 |
| ▸ | MMP3 | P08254 | 7/20 | 0.45 |
| ▸ | MMP8 | P22894 | 6/20 | 0.45 |
| ▸ | MMP12 | P39900 | 6/20 | 0.45 |
| ▸ | MMP14 | P50281 | 6/20 | 0.45 |
| ▸ | MMP16 | P51512 | 6/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313804 | 0.92 | ALDH1A1 (0.45) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL7325505 | 0.91 | MMP9 (0.46) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL7316141 | 0.91 | CA1 (0.44) | MMP2MMP13MMP9MMP1MMP14 | |
| SCHEMBL7322659 | 0.91 | MMP2 (0.47) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL7322414 | 0.89 | TP53 (0.45) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL7322985 | 0.86 | MMP2 (0.45) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL7325396 | 0.86 | MMP2 (0.41) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL7312473 | 0.86 | MCL1 (0.44) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL7317682 | 0.85 | MMP2 (0.41) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL7325574 | 0.84 | MMP2 (0.40) | MMP2MMP13MMP9MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |