Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.43 |
| ▸ | CPB1 | P15086 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14628582 | 1.00 | HTT (0.64) | HTTFOLH1KEAP1NFE2L2TGM2 | |
| SCHEMBL14598314 | 1.00 | HTT (0.64) | HTTFOLH1KEAP1NFE2L2TGM2 | |
| SCHEMBL7319378 | 0.99 | HTT (0.62) | HTTFOLH1KEAP1NFE2L2TGM2 | |
| SCHEMBL8029846 | 0.99 | HTT (0.62) | HTTFOLH1KEAP1NFE2L2TGM2 | |
| SCHEMBL7359305 | 0.96 | HTT (0.69) | HTTFOLH1KEAP1NFE2L2TGM2 | |
| SCHEMBL989685 | 0.92 | TGM2 (0.55) | HTTFOLH1KEAP1NFE2L2TGM2 | |
| SCHEMBL8039590 | 0.92 | HTT (0.52) | HTTFOLH1KEAP1NFE2L2TGM2 | |
| SCHEMBL7355388 | 0.91 | HTT (0.57) | HTTFOLH1KEAP1NFE2L2TGM2 | |
| SCHEMBL7381045 | 0.90 | HTT (0.50) | HTTFOLH1KEAP1NFE2L2TGM2 | |
| SCHEMBL7314617 | 0.89 | HTT (0.49) | HTTKEAP1NFE2L2TGM2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048911-A1 | MONOBACTAM ENZYME INHIBITORS | NAEJA PHARMACEUTICAL INC. (GB) | 1999-09-30 | — | — | WO | disclosed |
| EP-0646573-A1 | Preparation of protected and unprotected guanidino-substituted carboxylic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-05 | — | — | EP | disclosed |
| US-5326863-A | Antithrombin and antitrypsin activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-07-05 | — | — | US | disclosed |
| US-5250677-A | Anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-10-05 | — | — | US | disclosed |
| US-5175283-A | Enzyme inhibitors for antitrypsin or antithrombin as anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 1992-12-29 | — | — | US | disclosed |
| US-5110812-A | Treatment of pancreatitis; anticoagulants | BRISTOL-MYERS SQUIBB CO. (US) | 1992-05-05 | — | — | US | disclosed |
| US-5037819-A | Anticoagulant; treating pancreatitis | BRISTOL-MYERS SQUIBB COMPANY (US) | 1991-08-06 | — | — | US | disclosed |