Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 7/20 | 0.34 |
| ▸ | THRA | P10827 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313112 | 0.80 | PDE3B (0.40) | PDE3BPDE3AHPGDSMN1; SMN2NPC1 | |
| SCHEMBL7316554 | 0.79 | PDE3B (0.46) | PDE3BPDE3A | |
| SCHEMBL7312198 | 0.77 | PDE3B (0.44) | PDE3BPDE3AHPGDSMN1; SMN2NPC1 | |
| SCHEMBL7308929 | 0.76 | PDE3B (0.44) | PDE3BPDE3AHPGDSMN1; SMN2TSHR | |
| SCHEMBL7311914 | 0.75 | PDE3B (0.51) | PDE3BPDE3AHPGDSMN1; SMN2NPC1 | |
| SCHEMBL7305263 | 0.74 | PDE3B (0.47) | PDE3BPDE3A | |
| SCHEMBL7311818 | 0.71 | PDE3B (0.45) | PDE3BPDE3AHPGDKDM4EALDH1A1 | |
| SCHEMBL7320488 | 0.71 | PDE3B (0.45) | PDE3BPDE3AALDH1A1 | |
| SCHEMBL7307703 | 0.71 | PDE3B (0.45) | PDE3BPDE3ANPC1RAB9ATHRB | |
| SCHEMBL7311494 | 0.70 | PDE3B (0.52) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670434-A | ANTICOAGULANT, INOTROPIC AGENT | SYNTEX (U.S.A.) INC. (US) | 1987-06-02 | — | — | US | disclosed |