Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 9/20 | 0.53 |
| ▸ | MMP13 | P45452 | 9/20 | 0.53 |
| ▸ | MMP1 | P03956 | 8/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.53 |
| ▸ | NAMPT | P43490 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316683 | 0.93 | NAMPT (0.52) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7323200 | 0.93 | MMP13 (0.50) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7316583 | 0.91 | NAMPT (0.53) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7317524 | 0.86 | NAMPT (0.53) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7316220 | 0.86 | NAMPT (0.53) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7324861 | 0.84 | NAMPT (0.52) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7318343 | 0.84 | NAMPT (0.49) | MMP9MMP13MMP1NAMPTGAA | |
| SCHEMBL7319361 | 0.84 | MMP9 (0.56) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7410709 | 0.80 | MMP9 (0.52) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7318942 | 0.79 | MMP13 (0.52) | MMP9MMP13MMP1ADAM17NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |