Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010815 | 0.93 | BRD4 (0.39) | MAPK1BRD4KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL7458942 | 0.84 | ALDH1A1 (0.37) | KDM4ESMN1; SMN2FKBP1ACHRM2CHRM4 | |
| SCHEMBL24249167 | 0.84 | MAPK1 (0.44) | MAPK1KDM4EFKBP1ACHRM2CHRM4 | |
| SCHEMBL3689858 | 0.80 | BRD4 (0.41) | BRD4KDM4ESMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL3693041 | 0.77 | BRD4 (0.39) | BRD4KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3645840 | 0.77 | GSK3A (0.45) | MAPK1KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5480653 | 0.77 | PLA2G10 (0.40) | MAPK1KDM4ECHRM2CHRM1CHRM3 | |
| SCHEMBL14446813 | 0.75 | TP53 (0.39) | SMN1; SMN2FKBP1AALDH1A1 | |
| SCHEMBL31694645 | 0.74 | MAPK1 (0.52) | MAPK1SMN1; SMN2FKBP1ACHRM2CHRM4 | |
| SCHEMBL13069905 | 0.73 | HRH3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339669-A1 | Process for preparing indole-3-carboxylic acid esters of trans-hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-11-02 | — | — | EP | disclosed |