Sugi Predict

Sugi Predict / Compounds / SCHEMBL24249167

SCHEMBL24249167

SCHEMBL24249167

CC(C)(C)OC(=O)CN1C2CCCC1CC(=O)C2

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 1/20 0.44
▸ KMT2A Q03164 3/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ PLA2G10 O15496 2/20 0.39
▸ PLA2G5 P39877 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ CHRM2 P08172 2/20 0.34
▸ CHRM1 P11229 2/20 0.34
▸ CHRM3 P20309 2/20 0.34
▸ CHRM4 P08173 1/20 0.33
▸ OPRM1 P35372 1/20 0.33
▸ OPRL1 P41146 1/20 0.33
▸ FKBP1A P62942 2/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ RAMP1 O60894 3/20 0.32
▸ CALCRL Q16602 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5480653 0.94 PLA2G10 (0.40) MAPK1KMT2AL3MBTL1PLA2G10PLA2G5
SCHEMBL7319111 0.84 MAPK1 (0.47) MAPK1KMT2AL3MBTL1KDM4EALDH1A1
SCHEMBL24995604 0.83 KMT2A (0.41) KMT2AL3MBTL1PLA2G10PLA2G5ALDH1A1
SCHEMBL24875064 0.80 KMT2A (0.36) KMT2AL3MBTL1PLA2G10PLA2G5KDM4E
SCHEMBL24874876 0.80 KMT2A (0.36) KMT2AL3MBTL1PLA2G10PLA2G5KDM4E
SCHEMBL1010815 0.77 BRD4 (0.39) MAPK1KMT2AKDM4EALDH1A1OPRL1
SCHEMBL5577093 0.77 HRH3 (0.37) KMT2AL3MBTL1PLA2G10PLA2G5CHRM2
SCHEMBL25065577 0.76 PLA2G10 (0.39) MAPK1KMT2APLA2G10PLA2G5KDM4E
SCHEMBL12875999 0.76 CHRM2 (0.56) MAPK1KMT2AL3MBTL1KDM4ECHRM2
SCHEMBL156133 0.76 CHRM2 (0.56) MAPK1KMT2AL3MBTL1KDM4ECHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230069804-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2023-03-02 — — US disclosed
US-20230054781-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2023-02-23 — — US disclosed
US-20230009712-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2023-01-12 — — US disclosed
US-20220048902-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2022-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220048902-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING RBM17, SF3B1, SF3B5 MAPK1 3807/4885KMT2A 2420/4885L3MBTL1 231/4885
US-20230009712-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING RBM17, SF3B1, SF3B5 MAPK1 3807/4885KMT2A 2420/4885L3MBTL1 231/4885
US-20230069804-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING RBM17, SF3B1, SF3B5 MAPK1 3807/4885KMT2A 2420/4885L3MBTL1 231/4885
US-20230054781-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING RBM17, SF3B1, SF3B5 MAPK1 3807/4885KMT2A 2420/4885L3MBTL1 231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.