Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL923644 | 0.83 | LMNA (0.37) | LMNAALDH1A1MAPTKMT2ANR1H2 | |
| SCHEMBL7467650 | 0.75 | TP53 (0.48) | LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL4580271 | 0.73 | KDM4E (0.33) | LMNAMAPTKMT2AKDM4EPKM | |
| SCHEMBL1423435 | 0.71 | CDC25B (0.47) | ALDH1A1MAPTKMT2A | |
| SCHEMBL30946792 | 0.70 | LTC4S (0.36) | ALDH1A1KMT2ASCD | |
| SCHEMBL27284826 | 0.70 | LTC4S (0.36) | ALDH1A1KMT2ASCD | |
| SCHEMBL10439558 | 0.70 | CYP1A2 (0.44) | LMNAALDH1A1MAPTKMT2AKCNN4 | |
| SCHEMBL7310245 | 0.70 | CYP11B1 (0.34) | ALDH1A1KMT2AKDM4E | |
| SCHEMBL9585649 | 0.70 | TAAR1 (0.35) | — | |
| SCHEMBL6743058 | 0.68 | CYP11B1 (0.33) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0242973-B1 | INDOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1991-07-17 | — | — | EP | disclosed |