Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571780 | 0.85 | GABRG2 (0.42) | TP53ALOX12NPC1RAB9AGABRG2 | |
| SCHEMBL923644 | 0.81 | LMNA (0.37) | NPC1RAB9AMAPTHSD17B10ALDH1A1 | |
| SCHEMBL4963197 | 0.76 | TP53 (0.58) | TP53ALOX12NPC1RAB9AGABRG2 | |
| SCHEMBL7082785 | 0.76 | TP53 (0.42) | TP53ALOX12NPC1RAB9AGABRG2 | |
| SCHEMBL1564315 | 0.76 | TSHR (0.41) | TP53ALOX12NPC1RAB9AGABRG2 | |
| SCHEMBL312703 | 0.75 | TSHR (0.38) | NPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7319418 | 0.75 | LMNA (0.35) | MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL23496544 | 0.74 | NPC1 (0.48) | TP53ALOX12NPC1RAB9AMAPT | |
| SCHEMBL4958152 | 0.74 | TSHR (0.54) | TP53ALOX12NPC1RAB9AALDH1A1 | |
| SCHEMBL1562700 | 0.74 | MAPT (0.45) | TP53ALOX12NPC1RAB9AGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |
| US-5140034-A | Hydroxytryptamine receptor antagonists; psychological and gastrointestinal disorders | MERCK SHARP & DOHME LTD. (GB) | 1992-08-18 | — | — | US | disclosed |