Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL919742 | 0.87 | KIF11 (0.56) | ACEALDH1A1PPARGPPARAKIF11 | |
| SCHEMBL1158094 | 0.87 | KIF11 (0.56) | ACEALDH1A1PPARGPPARAKIF11 | |
| SCHEMBL1158095 | 0.87 | KIF11 (0.56) | ACEALDH1A1PPARGPPARAKIF11 | |
| Hydrochloric Acid SCHEMBL7323852 | 0.85 | KIF11 (0.55) | IDO1ACEALDH1A1PPARGPPARA | |
| Hydrochloric Acid SCHEMBL27713539 | 0.85 | KIF11 (0.55) | IDO1ACEALDH1A1PPARGPPARA | |
| SCHEMBL21955447 | 0.83 | MEN1 (0.43) | RAB9AMEN1KMT2AEPHX1 | |
| SCHEMBL20382878 | 0.83 | EPHX1 (0.51) | ACEALDH1A1KIF11LMNAEPHX1 | |
| SCHEMBL10519231 | 0.83 | ALDH1A1 (0.49) | IDO1ACEALDH1A1PPARGPPARA | |
| SCHEMBL9848804 | 0.83 | EPHX1 (0.53) | IDO1ACEALDH1A1PPARGPPARA | |
| SCHEMBL6951553 | 0.83 | ACE (0.46) | ACEALDH1A1PPARGPPARARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262436-A | Administering; enzyme inhibitor | SCHERING CORPORATION (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5061710-A | Atrial natriuretic factors | SCHERING CORPORATION (US) | 1991-10-29 | — | — | US | disclosed |
| US-4929641-A | DIURETICS, ANGIOTENSIN CONVERTING ENZYMES | SCHERING CORPORATION (US) | 1990-05-29 | — | — | US | disclosed |
| US-4801609-A | Mercapto-acylamino acid antihypertensives | SCHERING CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |