Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.61 |
| ▸ | MMP3 | P08254 | 2/20 | 0.61 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | TPH1 | P17752 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL7318515 | 0.87 | MMP2 (0.47) | MMP2MMP3MMP1SLC7A5MME | |
| Leucine SCHEMBL6416175 | 0.87 | MMP2 (0.47) | MMP2MMP3MMP1SLC7A5MME | |
| Leucine SCHEMBL7325203 | 0.87 | MMP2 (0.53) | MMP2MMP3MMP1MMELTA4H | |
| Leucine SCHEMBL7326725 | 0.85 | SLC7A5 (0.50) | MMP2MMP3MMP1SLC7A5KIF11 | |
| Leucine SCHEMBL7364033 | 0.85 | SLC7A5 (0.44) | MMP2MMP3MMP1SLC7A5KIF11 | |
| Leucine SCHEMBL6411762 | 0.85 | SLC7A5 (0.44) | MMP2MMP3MMP1SLC7A5MME | |
| Leucine SCHEMBL7367908 | 0.85 | SLC7A5 (0.44) | MMP2MMP3MMP1SLC7A5MME | |
| Leucine SCHEMBL6418640 | 0.85 | SLC7A5 (0.44) | MMP2MMP3MMP1SLC7A5KIF11 | |
| Leucine SCHEMBL6412971 | 0.84 | MMP2 (0.50) | MMP2MMP3MMP1MMELTA4H | |
| Leucine SCHEMBL7365687 | 0.84 | ALDH1A1 (0.47) | MMP2MMP3MMP1SLC7A5MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021360-A1 | SUBSTITUTED N-CARBOXYALKYLPEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS | MERCK & CO., INC. (US) | 1992-12-10 | — | — | WO | disclosed |