Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
| ▸ | MMP3 | P08254 | 4/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 7/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL6418640 | 1.00 | SLC7A5 (0.44) | SLC7A5MMP2MMP3MMP1MAPT | |
| Leucine SCHEMBL7367908 | 0.93 | SLC7A5 (0.44) | SLC7A5MMP2MMP3MMP1MAPT | |
| Leucine SCHEMBL6411762 | 0.93 | SLC7A5 (0.44) | SLC7A5MMP2MMP3MMP1MAPT | |
| Leucine SCHEMBL7318515 | 0.90 | MMP2 (0.47) | SLC7A5MMP2MMP3MMP1MME | |
| Leucine SCHEMBL6416175 | 0.90 | MMP2 (0.47) | SLC7A5MMP2MMP3MMP1MME | |
| Leucine SCHEMBL6412971 | 0.90 | MMP2 (0.50) | MMP2MMP3MMP1MMEACE | |
| Leucine SCHEMBL6413862 | 0.89 | ALDH1A1 (0.47) | SLC7A5MMP2MMP3MMP1MME | |
| Leucine SCHEMBL7365687 | 0.89 | ALDH1A1 (0.47) | SLC7A5MMP2MMP3MMP1MME | |
| Leucine SCHEMBL7327425 | 0.86 | SLC1A3 (0.43) | MMP2MMP3MMEACE | |
| Leucine SCHEMBL7319680 | 0.85 | MMP2 (0.61) | SLC7A5MMP2MMP3MMP1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028716-A1 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1998025597-A2 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 1998-06-18 | — | — | WO | disclosed |