Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672335 | 0.90 | MAPT (0.49) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL7088560 | 0.89 | KDM4E (0.50) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL7090585 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL7088585 | 0.81 | MEN1 (0.53) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL7316278 | 0.75 | ALDH1A1 (0.57) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL7093037 | 0.75 | MAPT (0.49) | KDM4EALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL7539507 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL7927865 | 0.74 | SIRT2 (0.43) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL8189626 | 0.74 | TSHR (0.55) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL2538829 | 0.73 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248746-B1 | PHOSPHODIESTERASE (PDE-IV) INHIBITOR FOR TREATMENT OF ASTHMA, ALLERGIES, ATOPIC DISEASES AND RHINITIS | EURO-CELTIQUE S.A. (LU) | 2001-06-19 | — | — | US | disclosed |