Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 10/20 | 0.51 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.50 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.50 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312576 | 0.84 | ORAI1 (0.69) | CRACR2ATRPC3ORAI1TRPC5LMNA | |
| SCHEMBL7326145 | 0.82 | CRACR2A (0.51) | CRACR2ATRPC3ORAI1TRPC5LMNA | |
| SCHEMBL7315476 | 0.79 | ORAI1 (0.75) | CRACR2ATRPC3ORAI1TRPC5LMNA | |
| SCHEMBL7323583 | 0.77 | CRACR2A (0.51) | CRACR2ATRPC3ORAI1 | |
| SCHEMBL7314421 | 0.72 | MAPT (0.45) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL8261109 | 0.72 | LMNA (0.51) | CRACR2ATRPC3ORAI1TRPC5LMNA | |
| SCHEMBL7314655 | 0.71 | ORAI1 (0.81) | CRACR2ATRPC3ORAI1TRPC5LMNA | |
| SCHEMBL7314753 | 0.70 | LMNA (0.60) | CRACR2ATRPC3ORAI1TRPC5LMNA | |
| SCHEMBL7972108 | 0.70 | LMNA (0.84) | CRACR2ATRPC3ORAI1TRPC5LMNA | |
| SCHEMBL7312377 | 0.70 | MAPT (0.40) | LMNAALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | claimed |
| EP-1068187-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 2001-01-17 | — | — | EP | claimed |
| WO-1999051580-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 1999-10-14 | — | — | WO | claimed |
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | disclosed |
| EP-1068187-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051580-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 1999-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | IL5, IL2, IL4 | CRACR2A 3286/4885TRPC3 4362/4885ORAI1 3522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.