SCHEMBL7320028

SCHEMBL7320028

O=S(=O)(O)CCCC(c1ccccc1)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 6/20 0.50
HTR2A P28223 5/20 0.50
GRM2 Q14416 1/20 0.44
GRM3 Q14832 1/20 0.44
SIGMAR1 Q99720 2/20 0.43
SRC P12931 1/20 0.42
MTNR1A P48039 1/20 0.42
MTNR1B P49286 1/20 0.42
ALDH1A1 P00352 1/20 0.41
EPHX2 P34913 1/20 0.41
CNR1 P21554 1/20 0.41
CNR2 P34972 1/20 0.41
TBXAS1 P24557 1/20 0.41
CYP2C19 P33261 1/20 0.40
KDM1A O60341 1/20 0.39
MAOB P27338 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9875298 0.94 HRH1 (0.48) HRH1HTR2AGRM2GRM3SIGMAR1
SCHEMBL7199830 0.92 HRH1 (0.47) HRH1HTR2AGRM2GRM3SIGMAR1
SCHEMBL21913847 0.88 HRH1 (0.46) HRH1HTR2ASRCMTNR1AMTNR1B
SCHEMBL7076936 0.86 RIPK1 (0.47) SRCALDH1A1CYP2C19
SCHEMBL972987 0.86 RIPK1 (0.47) SRCALDH1A1CYP2C19
SCHEMBL7075226 0.86 RIPK1 (0.47) SRCALDH1A1CYP2C19
SCHEMBL3139496 0.83 SRC (0.39) HRH1HTR2ASRCALDH1A1CYP2C19
SCHEMBL3129679 0.83 SRC (0.39) HRH1HTR2ASRCMTNR1AMTNR1B
SCHEMBL3129720 0.83 CYP2C19 (0.41) HRH1HTR2ASRCALDH1A1CYP2C19
SCHEMBL3139395 0.83 SRC (0.39) HRH1HTR2ASRCMTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0542846-A1 N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1993-05-26 EP disclosed
WO-1992002502-A1 N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1992-02-20 WO disclosed