Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 2/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | CPA1 | P15085 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446875 | 0.82 | CTNNB1 (0.49) | MMP9MMEACECPA1ACE2 | |
| SCHEMBL6448370 | 0.81 | TDP1 (0.54) | CASP1MMEACECPA1ACE2 | |
| SCHEMBL7276360 | 0.80 | MMP9 (0.45) | MMP9MMP8MMP2MMEACE | |
| SCHEMBL7303541 | 0.79 | CTNNB1 (0.46) | CASP1MMP9MMEACECPA1 | |
| SCHEMBL8484930 | 0.79 | CTNNB1 (0.51) | CTNNB1KMT2A | |
| SCHEMBL10589995 | 0.78 | KMT2A (0.54) | CASP1CTNNB1KMT2ALMNA | |
| SCHEMBL7319434 | 0.78 | NPC1 (0.49) | MMEACEKMT2ALMNA | |
| SCHEMBL7299907 | 0.78 | ALOX15 (0.46) | CASP1MMP9 | |
| SCHEMBL2752797 | 0.78 | ATM (0.60) | KMT2AATMLMNA | |
| SCHEMBL7294849 | 0.77 | CTNNB1 (0.44) | MMP9MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327877-A2 | Peptide-renininhibitors | MERCK PATENT GmbH (DE) | 1989-08-16 | — | — | EP | disclosed |
| EP-0292800-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |
| EP-0249096-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1987-12-16 | — | — | EP | disclosed |