Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 5/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.49 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316192 | 0.87 | CAPN1 (0.57) | CTSLCTSSCTSKCTSBMME | |
| SCHEMBL10119250 | 0.85 | PSMB5 (0.65) | PSMB5CTSLCTSSCTSKGPR139 | |
| SCHEMBL7318555 | 0.85 | PSMB5 (0.65) | PSMB5CTSLCTSSCTSKGPR139 | |
| Hydrochloric Acid SCHEMBL7348808 | 0.83 | LTA4H (0.46) | LTA4HMME | |
| SCHEMBL10118961 | 0.82 | USP30 (0.56) | PSMB5CTSLCTSSCTSKCTSB | |
| SCHEMBL7327671 | 0.81 | PSMB5 (0.58) | PSMB5CTSLCTSSCTSKCTSB | |
| SCHEMBL7315385 | 0.81 | PSMB5 (0.58) | PSMB5CTSLCTSSCTSKCTSB | |
| SCHEMBL7315389 | 0.81 | PSMB5 (0.60) | PSMB5CTSLCTSSCTSKGPR139 | |
| SCHEMBL7322353 | 0.81 | CAPN1 (0.55) | CTSLCTSSCTSKCTSBMME | |
| SCHEMBL10118946 | 0.80 | CTSS (0.67) | PSMB5CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| US-5158936-A | Treating or prevention of tissue damage, inflammation, bone resporpption and muscular dystrophy | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055451-A | Prevent tissue damage | SYNTEX INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0272671-A2 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD. (CH) | 1988-06-29 | — | — | EP | disclosed |