Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 7/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | CENPE | Q02224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316196 | 0.88 | CAPN1 (0.52) | CTSLCTSSCTSK | |
| Hydrochloric Acid SCHEMBL7348813 | 0.84 | LTA4H (0.42) | — | |
| SCHEMBL7327681 | 0.81 | PLAT (0.44) | CTSL | |
| SCHEMBL10119250 | 0.80 | PSMB5 (0.65) | PSMB5CTSLCTSSCTSKGPR139 | |
| SCHEMBL7318555 | 0.80 | PSMB5 (0.65) | PSMB5CTSLCTSSCTSKGPR139 | |
| SCHEMBL7317359 | 0.77 | CTSL (0.44) | CTSLCTSSCTSK | |
| SCHEMBL10118961 | 0.77 | USP30 (0.56) | PSMB5CTSLCTSSCTSK | |
| SCHEMBL7320814 | 0.77 | CAPN1 (0.56) | CTSLCTSK | |
| SCHEMBL10118963 | 0.76 | CTSL (0.50) | KLKB1PSMB5CTSLCTSSCTSK | |
| SCHEMBL7320085 | 0.76 | PSMB5 (0.51) | PSMB5CTSLCTSSCTSKBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| US-5158936-A | Treating or prevention of tissue damage, inflammation, bone resporpption and muscular dystrophy | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055451-A | Prevent tissue damage | SYNTEX INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0272671-A2 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD. (CH) | 1988-06-29 | — | — | EP | disclosed |