SCHEMBL7320109

SCHEMBL7320109

O=C(NCC1CCCC1)C1CCc2ccccc2O1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 2/20 0.46
HDAC1 Q13547 2/20 0.46
HDAC2 Q92769 2/20 0.46
F2 P00734 2/20 0.45
EPHX1 P07099 2/20 0.44
CA2 P00918 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
P2RX7 Q99572 1/20 0.42
SSTR4 P31391 1/20 0.41
POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11530821 0.79 LMNA (0.47) HDAC3HDAC1HDAC2CA2HDAC4
SCHEMBL24496758 0.79 HDAC3 (0.52) HDAC3HDAC1HDAC2CA2HDAC4
SCHEMBL29587707 0.79 HDAC3 (0.52) HDAC3HDAC1HDAC2CA2HDAC4
SCHEMBL24496757 0.79 HDAC3 (0.52) HDAC3HDAC1HDAC2CA2HDAC4
SCHEMBL30982161 0.79 HPGD (0.51) HDAC3HDAC1HDAC2HDAC4HDAC7
SCHEMBL8315667 0.79 EPHX1 (0.41) EPHX1CA2MEN1KMT2A
SCHEMBL30982230 0.78 CYP2D6 (0.46) HDAC3HDAC1HDAC2CA2HDAC4
SCHEMBL8969209 0.78 MEN1 (0.65) HDAC3HDAC1HDAC2HDAC4HDAC7
SCHEMBL29212165 0.77 HDAC3 (0.54) HDAC3HDAC1HDAC2CA2HDAC4
SCHEMBL9437666 0.77 HDAC3 (0.48) HDAC3HDAC1HDAC2CA2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5962513-A CENTRAL NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS BAYER AKTIENGESELLSCHAFT (DE) 1999-10-05 US disclosed
US-5468882-A Serotoninergic agents; central nervous system and psychological disorders BAYER AKTIENGESELLSCHAFT (DE) 1995-11-21 US disclosed
US-5318988-A Treating psychoses BAYER AKTIENGESELLSCHAFT (DE) 1994-06-07 US disclosed