Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9290880 | 0.80 | SSTR4 (0.45) | CA2HPGD | |
| SCHEMBL9379406 | 0.80 | MEN1 (0.46) | EPHX1KMT2AMEN1HPGD | |
| SCHEMBL7320109 | 0.79 | HDAC3 (0.46) | EPHX1CA2KMT2AMEN1 | |
| SCHEMBL8317168 | 0.76 | P2RX7 (0.44) | EPHX1KMT2AMEN1MAPT | |
| SCHEMBL7336911 | 0.76 | CA2 (0.43) | CA2HPGD | |
| SCHEMBL4197198 | 0.76 | CA2 (0.43) | CA2HPGD | |
| SCHEMBL9379705 | 0.74 | CA2 (0.43) | CA2HPGDDRD2ALDH1A1NPSR1 | |
| SCHEMBL6493103 | 0.74 | GABRA1 (0.47) | CA2HPGDDRD2 | |
| SCHEMBL5695473 | 0.74 | CA2 (0.46) | CA2HPGD | |
| SCHEMBL7309998 | 0.72 | HTR1A (0.57) | CA2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540914-B1 | 2-Aminomethylchromans as active ingredients in medicaments for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1999-06-02 | — | — | EP | disclosed |
| EP-0540914-A1 | 2-Aminomethylchromans as active ingredients in medicaments for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1993-05-12 | — | — | EP | disclosed |