Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 17/20 | 0.55 |
| ▸ | MMP9 | P14780 | 16/20 | 0.55 |
| ▸ | MMP1 | P03956 | 15/20 | 0.55 |
| ▸ | MMP2 | P08253 | 3/20 | 0.55 |
| ▸ | MMP8 | P22894 | 3/20 | 0.55 |
| ▸ | MMP12 | P39900 | 3/20 | 0.55 |
| ▸ | MMP14 | P50281 | 3/20 | 0.55 |
| ▸ | MMP16 | P51512 | 3/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.53 |
| ▸ | MMP3 | P08254 | 2/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320167 | 0.78 | FFAR4 (0.70) | MMP13MMP9MMP1MMP2MMP8 | |
| SCHEMBL7323902 | 0.71 | MMP13 (1.00) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7313705 | 0.71 | MMP13 (0.74) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7443729 | 0.70 | MMP13 (1.00) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7325101 | 0.69 | MMP13 (0.84) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL5898955 | 0.68 | MMP9 (0.62) | MMP13MMP9MMP1MMP2MMP8 | |
| SCHEMBL7324037 | 0.68 | MMP9 (0.70) | MMP13MMP9MMP1MMP2MMP8 | |
| SCHEMBL5159892 | 0.67 | FFAR4 (0.74) | ADAM17FFAR4 | |
| SCHEMBL7322031 | 0.67 | FFAR4 (0.74) | ADAM17FFAR4 | |
| SCHEMBL7318221 | 0.66 | MMP13 (0.83) | MMP13MMP9MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |