Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 2/20 | 0.41 |
| ▸ | CPA2 | P48052 | 2/20 | 0.41 |
| ▸ | CPA4 | Q9UI42 | 2/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 8/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 7/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | KLK8 | O60259 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | KLK2 | P20151 | 1/20 | 0.38 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.38 |
| ▸ | IL1RN | P18510 | 2/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324109 | 0.92 | CPA1 (0.39) | CPA1CPA2CPA4ERAP1ERAP2 | |
| SCHEMBL6412346 | 0.89 | CPA1 (0.45) | CPA1CPA2CPA4ERAP1ERAP2 | |
| SCHEMBL7323541 | 0.85 | ANPEP (0.38) | CPA1CPA2CPA4MMEECE1 | |
| SCHEMBL7328790 | 0.82 | SLC1A3 (0.44) | MMEECE1ACE2 | |
| SCHEMBL7309270 | 0.82 | CTSL (0.46) | CPA1CPA2CPA4MMEECE1 | |
| SCHEMBL7329474 | 0.82 | CTSL (0.46) | CPA1CPA2CPA4MMEECE1 | |
| SCHEMBL7309259 | 0.82 | CTSL (0.46) | CPA1CPA2CPA4MMEECE1 | |
| SCHEMBL7316834 | 0.82 | CPA1 (0.40) | CPA1CPA2CPA4ERAP1ERAP2 | |
| SCHEMBL7323423 | 0.82 | TACR3 (0.36) | ANPEPLTA4HMMP2MMP9 | |
| SCHEMBL7321472 | 0.82 | CA12 (0.37) | CPA1CPA2CPA4MMEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612324-A1 | PHOSPHONOPEPTIDES WITH COLLAGENASE INHIBITING ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993009136-A1 | PHOSPHONOPEPTIDES WITH COLLAGENASE INHIBITING ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1993-05-13 | — | — | WO | disclosed |