Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | CPA1 | P15085 | 2/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709641 | 0.82 | LTB4R (0.41) | LTB4RLTB4R2 | |
| SCHEMBL30088676 | 0.77 | ALDH1A1 (0.41) | — | |
| SCHEMBL9555874 | 0.75 | KMT2A (0.53) | MMP12MMP2MMP3CPA1CPB1 | |
| SCHEMBL1405655 | 0.75 | KMT2A (0.53) | MMP12MMP2MMP3CPA1CPB1 | |
| SCHEMBL2376130 | 0.73 | SLC7A5 (0.50) | — | |
| SCHEMBL2376135 | 0.73 | SLC7A5 (0.50) | — | |
| SCHEMBL7322599 | 0.72 | MMP1 (0.39) | MMP12MMP2MMP3MMP9MMP13 | |
| SCHEMBL10734883 | 0.72 | CPA1 (0.67) | MMP12MMP2CPA1CPB1CPA3 | |
| SCHEMBL9196227 | 0.72 | CPA1 (0.67) | MMP12MMP2CPA1CPB1CPA3 | |
| SCHEMBL11311301 | 0.72 | CPA1 (0.67) | MMP12MMP2CPA1CPB1CPA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229420-A | Renin inhibitor | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1990000051-A1 | ETHEREAL N-TERMINAL AMINODIOL AMINO ACID DERIVATIVES AS ANTI-HYPERTENSIVE AGENTS | G.D. SEARLE & CO. (US) | 1990-01-11 | — | — | WO | disclosed |
| EP-0349921-A2 | Etheral n-terminal aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-01-10 | — | — | EP | disclosed |