Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.52 |
| ▸ | ITGAV | P06756 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | ECE1 | P42892 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656725 | 0.94 | CTSL (0.58) | CTSLFOLH1SIRT2SIRT1CTSS | |
| SCHEMBL10421088 | 0.91 | FOLH1 (0.62) | CTSLFOLH1SIRT2SIRT1CTSS | |
| SCHEMBL4740486 | 0.90 | SIRT2 (0.56) | CTSLSIRT2SIRT1CTSS | |
| SCHEMBL7996588 | 0.90 | CTSL (0.57) | CTSLFOLH1SIRT2SIRT1CTSS | |
| SCHEMBL10772916 | 0.90 | SIRT2 (0.55) | CTSLSIRT2SIRT1CTSSITGB3 | |
| Hydrochloric Acid SCHEMBL4740911 | 0.89 | SIRT2 (0.55) | CTSLSIRT2SIRT1CTSS | |
| SCHEMBL3937813 | 0.88 | PPARA (0.56) | CTSSPPARAPPARG | |
| SCHEMBL29396254 | 0.88 | PPARA (0.56) | CTSSPPARAPPARG | |
| SCHEMBL8387978 | 0.88 | FOLH1 (0.65) | CTSLFOLH1SIRT2SIRT1CTSS | |
| SCHEMBL10419670 | 0.87 | CTSL (0.69) | CTSLFOLH1SIRT2SIRT1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358398-B1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | Pfizer Limited (GB) | 1993-03-10 | — | — | EP | disclosed |
| EP-0249445-A2 | Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-12-16 | — | — | EP | disclosed |