Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.66 |
| ▸ | ALB | P02768 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330064 | 0.89 | OPRK1 (0.67) | OPRK1LMNAPDE3AALBMEN1 | |
| Cinolazepam SCHEMBL30338063 | 0.87 | OPRK1 (0.53) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Cinolazepam SCHEMBL4457397 | 0.87 | OPRK1 (0.53) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| Cinolazepam SCHEMBL415075 | 0.87 | OPRK1 (0.53) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| SCHEMBL25409870 | 0.85 | OPRK1 (0.52) | OPRK1LMNAPDE3AALBPDE4D | |
| SCHEMBL31366637 | 0.85 | OPRK1 (0.52) | OPRK1LMNAPDE3AALBPDE4D | |
| SCHEMBL25409864 | 0.85 | OPRK1 (0.52) | OPRK1LMNAPDE3AALBPDE4D | |
| SCHEMBL7328677 | 0.84 | LMNA (0.47) | OPRK1LMNAPDE3APDE4DHDAC1 | |
| SCHEMBL7318902 | 0.84 | PDE4D (0.48) | OPRK1LMNAPDE3AALBMEN1 | |
| Cinolazepam SCHEMBL28142897 | 0.84 | OPRK1 (0.50) | OPRK1LMNAPDE3APDE4DCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4388313-A | Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof | GEROT-PHARMAZEUTIKA GESELLSCHAFT M.B.H. (AT) | 1983-06-14 | — | — | US | claimed |
| US-4388313-A | Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof | GEROT-PHARMAZEUTIKA GESELLSCHAFT M.B.H. (AT) | 1983-06-14 | — | — | US | disclosed |