Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7320957 | 1.00 | S1PR1 (0.51) | S1PR1HRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7325843 | 0.95 | SLC6A4 (0.53) | S1PR1HRH3KDM4ESLC6A4SLC6A3 | |
| SCHEMBL7325847 | 0.95 | SLC6A4 (0.53) | S1PR1HRH3KDM4ESLC6A4SLC6A3 | |
| Oxalic Acid SCHEMBL7327867 | 0.85 | SLC6A4 (0.65) | S1PR1HRH3KDM4ESMN1; SMN2SLC6A4 | |
| Oxalic Acid SCHEMBL7327873 | 0.85 | SLC6A4 (0.65) | S1PR1HRH3KDM4ESMN1; SMN2SLC6A4 | |
| Oxalic Acid SCHEMBL7245307 | 0.82 | MCHR1 (0.49) | S1PR1HRH3KDM4EALDH1A1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL7245310 | 0.82 | MCHR1 (0.49) | S1PR1HRH3KDM4EALDH1A1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL7243351 | 0.82 | HCRTR1 (0.55) | S1PR1HRH3KDM4EALDH1A1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL7243355 | 0.82 | HCRTR1 (0.55) | S1PR1HRH3KDM4EALDH1A1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL9527661 | 0.82 | ALDH1A1 (0.48) | HRH3KDM4EALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542846-A1 | N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-05-26 | — | — | EP | disclosed |
| WO-1992002502-A1 | N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-02-20 | — | — | WO | disclosed |