Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27613454 | 0.78 | KMT2A (0.54) | KMT2ANPC1MEN1KDM4EALDH1A1 | |
| SCHEMBL6835178 | 0.78 | GABRA1 (0.62) | KMT2AGABRA1GABRB1GABRG2GABRB3 | |
| SCHEMBL29061079 | 0.78 | GABRA1 (0.44) | KMT2ANPC1MEN1GABRA1GABRB1 | |
| SCHEMBL10517797 | 0.77 | HPGD (0.46) | KMT2ANPC1MEN1KDM4EALDH1A1 | |
| SCHEMBL29119392 | 0.76 | HPGD (0.47) | KMT2ANPC1MEN1GABRA1GABRG2 | |
| SCHEMBL2046630 | 0.75 | KMT2A (0.56) | KMT2ANPC1MEN1KDM4EALDH1A1 | |
| SCHEMBL7308873 | 0.75 | CTSD (0.43) | KMT2ANPC1MEN1GABRA1GABRB1 | |
| SCHEMBL9971654 | 0.73 | KMT2A (0.41) | KMT2AMEN1GABRA1GABRB1GABRG2 | |
| SCHEMBL9641182 | 0.71 | KDM4E (0.54) | KMT2ANPC1MEN1KDM4EALDH1A1 | |
| SCHEMBL5327362 | 0.71 | KMT2A (0.52) | KMT2ANPC1MEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |