Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 7/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347474 | 0.77 | CRBN (0.51) | CYP11B1CYP11B2CRBNPDE3BPDE3A | |
| SCHEMBL9700769 | 0.68 | — | — | |
| SCHEMBL9700774 | 0.68 | ALDH1A1 (0.32) | — | |
| SCHEMBL7264344 | 0.68 | CYP11B1 (0.53) | CYP11B1CYP11B2CYP19A1PDE3BPDE3A | |
| SCHEMBL10680998 | 0.65 | TUBB4A (0.33) | — | |
| SCHEMBL7272102 | 0.65 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP19A1PDE3BPDE3A | |
| SCHEMBL14866031 | 0.65 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP19A1CRBNPDE3B | |
| SCHEMBL10680277 | 0.64 | PDE3B (0.41) | PDE3BPDE3APDE2A | |
| SCHEMBL18513259 | 0.63 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP19A1CRBNBRD4 | |
| SCHEMBL9699790 | 0.62 | ALDH1A1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900839-A | SUBSTITUTED PHENYLPROPENAMIDES | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0166533-A1 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-01-02 | — | — | EP | disclosed |