Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700738 | 0.80 | HSD11B1 (0.34) | CRBNPDE3BPDE3ATBXAS1MAPT | |
| SCHEMBL9700875 | 0.80 | CYP11B1 (0.43) | CRBNPDE3BPDE3ATBXAS1ALDH1A1 | |
| SCHEMBL7321973 | 0.77 | CYP11B1 (0.42) | CRBNPDE3BPDE3ATBXAS1CYP1A2 | |
| SCHEMBL9701071 | 0.74 | HSD11B1 (0.34) | MAPTALDH1A1NR3C1 | |
| SCHEMBL5618732 | 0.71 | ALDH1A1 (0.46) | CRBNPDE3BPDE3ATBXAS1MAPT | |
| SCHEMBL10681028 | 0.71 | PDE3B (0.61) | PDE3BPDE3AMEN1KMT2A | |
| SCHEMBL20929265 | 0.70 | PARP1 (0.43) | — | |
| SCHEMBL433753 | 0.70 | PKM (0.58) | CRBNPDE3BPDE3ATBXAS1MAPT | |
| SCHEMBL29199433 | 0.70 | PKM (0.58) | CRBNPDE3BPDE3ATBXAS1MAPT | |
| SCHEMBL31521527 | 0.69 | CRBN (0.58) | CRBNPDE3BPDE3ATBXAS1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900839-A | SUBSTITUTED PHENYLPROPENAMIDES | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0166533-A1 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-01-02 | — | — | EP | disclosed |