Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.40 |
| ▸ | MMP13 | P45452 | 8/20 | 0.40 |
| ▸ | MMP1 | P03956 | 7/20 | 0.40 |
| ▸ | MMP9 | P14780 | 7/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318793 | 0.87 | MMP9 (0.53) | NAMPTADAM17MMP13MMP1MMP9 | |
| SCHEMBL7320002 | 0.80 | MMP9 (0.47) | NAMPTADAM17MMP13MMP1MMP9 | |
| SCHEMBL7322747 | 0.80 | NAMPT (0.44) | NAMPTADAM17MMP13MMP1MMP9 | |
| SCHEMBL7322273 | 0.78 | NAMPT (0.48) | NAMPTADAM17MMP13MMP1MMP9 | |
| SCHEMBL7324868 | 0.77 | MMP9 (0.50) | NAMPTADAM17MMP13MMP1MMP9 | |
| SCHEMBL7311165 | 0.77 | NAMPT (0.47) | NAMPTADAM17MMP13MMP1MMP9 | |
| SCHEMBL7320609 | 0.76 | MMP9 (0.49) | NAMPTADAM17MMP13MMP1MMP9 | |
| SCHEMBL7325108 | 0.76 | MMP13 (0.47) | NAMPTADAM17MMP13MMP1MMP9 | |
| SCHEMBL7315190 | 0.75 | MMP9 (0.46) | NAMPTADAM17MMP13MMP1MMP9 | |
| SCHEMBL7316691 | 0.73 | MMP13 (0.48) | NAMPTADAM17MMP13MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |