Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CHRND | Q07001 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312094 | 0.81 | LMNA (0.53) | LMNANPSR1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL7322612 | 0.81 | CHRM3 (0.45) | LMNANPSR1CHRM3CHRNA1CHRNG | |
| SCHEMBL29722 | 0.80 | CHRM3 (0.46) | CHRM3GAATDP1 | |
| SCHEMBL7312957 | 0.78 | LMNA (0.43) | LMNANPSR1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL5475178 | 0.78 | PDK2 (0.38) | LMNANPSR1CHRM3OPRM1OPRD1 | |
| SCHEMBL7320476 | 0.77 | LMNA (0.42) | LMNANPSR1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL28612399 | 0.76 | PDK2 (0.45) | LMNANPSR1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL22048471 | 0.73 | CHRM3 (0.44) | CHRM3CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL25705368 | 0.71 | AHR (0.41) | LMNANPSR1HDAC4OPRM1OPRD1 | |
| SCHEMBL5474669 | 0.71 | AHR (0.49) | LMNACHRM3OPRM1OPRD1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |