Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CHRND | Q07001 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312094 | 0.81 | LMNA (0.53) | LMNANPSR1HDAC4OPRM1OPRD1 | |
| SCHEMBL7310248 | 0.81 | BCHE (0.39) | LMNANPSR1BCHEOPRM1OPRD1 | |
| SCHEMBL7322303 | 0.80 | P2RX1 (0.44) | LMNANPSR1BCHESLC6A2SLC6A3 | |
| SCHEMBL7312957 | 0.78 | LMNA (0.43) | LMNANPSR1HDAC4OPRM1OPRD1 | |
| SCHEMBL7322189 | 0.77 | LMNA (0.45) | LMNANPSR1HDAC4OPRM1OPRD1 | |
| SCHEMBL13940107 | 0.76 | TDP1 (0.36) | BCHEPDK2MAPTMEN1HPGD | |
| SCHEMBL28612399 | 0.76 | PDK2 (0.45) | LMNANPSR1HDAC4OPRM1OPRD1 | |
| SCHEMBL22169961 | 0.75 | POLB (0.31) | POLBCASP6 | |
| SCHEMBL888093 | 0.75 | NPC1 (0.40) | NPSR1BCHESLC6A2SLC6A3MAPT | |
| SCHEMBL21880254 | 0.73 | BCHE (0.35) | LMNANPSR1BCHESLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |