Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | CHRNG | P07510 | 1/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CHRND | Q07001 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312094 | 0.82 | LMNA (0.53) | LMNANPSR1HDAC4OPRM1OPRD1 | |
| SCHEMBL7315720 | 0.82 | KIF11 (0.46) | LMNAKDM4EPKMOPRM1OPRD1 | |
| SCHEMBL7322102 | 0.79 | P2RX1 (0.46) | LMNAKDM4EPKMPDK2KIF11 | |
| SCHEMBL7320476 | 0.78 | LMNA (0.42) | LMNANPSR1KDM4EHDAC4OPRM1 | |
| SCHEMBL7322189 | 0.78 | LMNA (0.45) | LMNANPSR1KDM4EHDAC4OPRM1 | |
| SCHEMBL28612399 | 0.77 | PDK2 (0.45) | LMNANPSR1HDAC4OPRM1OPRD1 | |
| SCHEMBL5135584 | 0.72 | LMNA (0.38) | LMNANPSR1KDM4EPKMHDAC4 | |
| SCHEMBL9644144 | 0.70 | PDK2 (0.42) | LMNANPSR1KDM4EPKMPDK2 | |
| SCHEMBL18723336 | 0.70 | ALDH1A1 (0.46) | LMNANPSR1HDAC4OPRM1OPRD1 | |
| SCHEMBL11629890 | 0.69 | ALDH1A1 (0.38) | LMNAKDM4EPKMOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |