Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.40 |
| ▸ | EGFR | P00533 | 8/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.40 |
| ▸ | ABL1 | P00519 | 6/20 | 0.40 |
| ▸ | HCK | P08631 | 6/20 | 0.40 |
| ▸ | KDR | P35968 | 6/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.40 |
| ▸ | MTOR | P42345 | 6/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.40 |
| ▸ | PRKDC | P78527 | 6/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312127 | 0.87 | PDE5A (0.42) | SRCEGFRPIK3CDABL1HCK | |
| SCHEMBL7316542 | 0.84 | EGFR (0.37) | SRCEGFRPIK3CDABL1HCK | |
| SCHEMBL7313010 | 0.80 | EGFR (0.36) | SRCEGFRPIK3CDABL1HCK | |
| SCHEMBL7320063 | 0.79 | EGFR (0.39) | SRCEGFRPIK3CDABL1HCK | |
| SCHEMBL29611593 | 0.69 | PDE5A (0.62) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL5595521 | 0.69 | HCRTR1 (0.38) | DGAT1HCRTR1HCRTR2PDE5APDE1A | |
| SCHEMBL21138767 | 0.67 | KDR (0.53) | SRCEGFRPIK3CDABL1HCK | |
| SCHEMBL8987482 | 0.66 | PDE5A (0.37) | SRCEGFRPIK3CDABL1HCK | |
| SCHEMBL716026 | 0.64 | HCRTR1 (0.39) | HCRTR1HCRTR2PDE5APDE1APDE1B | |
| SCHEMBL7316083 | 0.64 | KDM4E (0.46) | SRCEGFRPIK3CDABL1HCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |