Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.39 |
| ▸ | BTK | Q06187 | 4/20 | 0.39 |
| ▸ | ABL1 | P00519 | 8/20 | 0.39 |
| ▸ | SRC | P12931 | 8/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.39 |
| ▸ | HCK | P08631 | 7/20 | 0.39 |
| ▸ | KDR | P35968 | 7/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.39 |
| ▸ | MTOR | P42345 | 7/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.39 |
| ▸ | PRKDC | P78527 | 7/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.39 |
| ▸ | PDE4A | P27815 | 4/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312127 | 0.91 | PDE5A (0.42) | EGFRBTKABL1SRCPIK3CD | |
| SCHEMBL7313010 | 0.90 | EGFR (0.36) | EGFRBTKABL1SRCPIK3CD | |
| SCHEMBL7322196 | 0.79 | SRC (0.40) | EGFRBTKABL1SRCPIK3CD | |
| SCHEMBL8987482 | 0.73 | PDE5A (0.37) | EGFRABL1SRCPIK3CDHCK | |
| SCHEMBL7317680 | 0.73 | SRC (0.38) | EGFRABL1SRCPIK3CDHCK | |
| SCHEMBL7316542 | 0.71 | EGFR (0.37) | EGFRBTKABL1SRCPIK3CD | |
| SCHEMBL7312223 | 0.70 | TLR9 (0.39) | EGFRABL1SRCPIK3CDHCK | |
| SCHEMBL7315692 | 0.70 | SRC (0.40) | ABL1SRCPRKCIALDH1A1HSD17B10 | |
| SCHEMBL9081191 | 0.70 | PDE4A (0.36) | EGFRABL1SRCPIK3CDHCK | |
| SCHEMBL7315674 | 0.69 | SRC (0.39) | EGFRABL1SRCPIK3CDHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |