Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 17/20 | 0.52 |
| ▸ | MMP1 | P03956 | 15/20 | 0.52 |
| ▸ | MMP9 | P14780 | 16/20 | 0.49 |
| ▸ | MMP12 | P39900 | 3/20 | 0.48 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | MMP14 | P50281 | 2/20 | 0.48 |
| ▸ | MMP16 | P51512 | 2/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.48 |
| ▸ | BMP1 | P13497 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322103 | 0.92 | MMP1 (0.44) | MMP13MMP1MMP9MMP2BMP1 | |
| SCHEMBL7321489 | 0.85 | MMP13 (0.47) | MMP13MMP1MMP9MMP12MMP3 | |
| SCHEMBL7318219 | 0.85 | MMP13 (0.56) | MMP13MMP1MMP9MMP12MMP3 | |
| SCHEMBL7322130 | 0.83 | MMP13 (0.47) | MMP13MMP1MMP9MMP12MMP3 | |
| SCHEMBL7322292 | 0.81 | MMP13 (0.68) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL6815791 | 0.81 | MMP13 (0.60) | MMP13MMP1MMP9MMP12MMP2 | |
| SCHEMBL7323687 | 0.78 | FFAR4 (0.53) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL7320197 | 0.77 | MMP2 (0.46) | MMP13MMP1MMP9MMP12MMP3 | |
| SCHEMBL7324074 | 0.77 | HTT (0.48) | MMP13MMP1 | |
| SCHEMBL7825679 | 0.76 | MMP13 (0.44) | MMP13MMP1MMP9MMP12MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | claimed |
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |