Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.69 |
| ▸ | PGR | P06401 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314377 | 0.85 | CRBN (0.62) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL11042336 | 0.85 | NR3C1 (0.84) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| Hydrochloric Acid SCHEMBL10838441 | 0.84 | HTR1A (0.65) | ALOX15KMT2APOLBMAPTDRD2 | |
| SCHEMBL11052649 | 0.83 | NR3C1 (0.71) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| Vesnarinone SCHEMBL29402965 | 0.82 | PDE3B (1.00) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| Vesnarinone SCHEMBL50993 | 0.82 | PDE3B (1.00) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL7321881 | 0.82 | NR3C1 (0.56) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| Vesnarinone SCHEMBL6243858 | 0.82 | PDE3B (1.00) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL7319943 | 0.82 | NR3C1 (0.66) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL11042441 | 0.82 | NR3C1 (0.66) | NR3C1PGRSLC6A4KCNH2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845100-A | WITH HYPOTENSIVE AND ANTIINFLAMMATORY ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-04 | — | — | US | disclosed |
| EP-0202760-A2 | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-26 | — | — | EP | disclosed |