Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.60 |
| ▸ | PDE4A | P27815 | 11/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.54 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27472680 | 0.91 | PDE4D (0.68) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL72993 | 0.90 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL4162765 | 0.87 | PDE5A (0.70) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL7910791 | 0.87 | ALDH1A1 (0.68) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL7909156 | 0.87 | PDE4B (0.61) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL6881789 | 0.86 | PDE4D (0.60) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL6586713 | 0.85 | PDE4D (0.59) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL8769611 | 0.84 | PDE4A (0.54) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL4825142 | 0.83 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL5072124 | 0.83 | CYP1A2 (0.76) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |
| EP-0626957-B1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1999-03-03 | — | — | EP | disclosed |
| US-5622977-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5580888-A | Styryl derivatives as anti-inflammatory agents | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0626957-A1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994014800-A1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |